Prospective roles for miRNAs during embryonic gonad development into the chicken
AMH sign transduction via the TGF-Я signalling path and possible involvement of miRNAs.
AMH binds specifically towards the AMH receptor (AMHR2), which activates either activin receptor 1 (ACVR1), or bone tissue morphogenic receptor 1A (BMPR1A), or 1B (BMPR1B). Activated ACVR1 and BMPR1A transduce AMH signals by activating SMAD signalling proteins (SMAD1, 5 or 8), with the assistance of ZEB1. BMPR1B competitively antagonises SMAD activation. ZEB2 and TGIF bind to SMADs and SMAD DNA binding internet web web sites, correspondingly, to prevent signalling. MiR-101 ( red) is predicted to focus on BMPR1B, ZEB1 and 2, and TGIF transcripts, and will modulate signalling that is TGF-Я.